The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2009
Filed:
Sep. 17, 2001
Venkatraman Ramakrishnan, Cambridge, GB;
Brian Thomas Wimberly, Guilford, CT (US);
Ditlev Egeskov Brodersen, Cambridge, GB;
Andrew Philip Carter, Cambridge, GB;
William Melvon Clemons, Jr., Boston, MA (US);
Venkatraman Ramakrishnan, Cambridge, GB;
Brian Thomas Wimberly, Guilford, CT (US);
Ditlev Egeskov Brodersen, Cambridge, GB;
Andrew Philip Carter, Cambridge, GB;
William Melvon Clemons, Jr., Boston, MA (US);
University of Utah Research Foundation, Salt Lake City, UT (US);
Medical Research Council, London, GB;
Abstract
The invention provides an X-ray crystal structure of the 30S ribosome, obtained from30S subunit, having a tetragonal space group P422 with unit cell dimensions of a=401.4±4.0 Å, b=401.4±4.0 Å, c=175.9±5.0 Å. An advantageous feature of the structure is that it diffracts beyond 3 Å resolution. The invention also provides a crystal of 30S having the three dimensional atomic coordinates of the 30S ribosome, the coordinates being provided in Tables 1A and 1B. The data may be used for the rational design and modelling of inhibitors for the 30S ribosome, which have potential use as antibiotics.