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1 out of 832,843 Years Active: 2019-2025
Title: **Inventor Dhruv Sareen: Pioneering Innovations in Microfluidic Technologies**
Introduction
Dhruv Sareen, an accomplished inventor based in Porter Ranch, California, is recognized for his groundbreaking work in the fields of microfluidics and biomedical engineering. With a remarkable portfolio that includes 13 patents, Sareen's innovations aim to advance medical research and treatment, particularly concerning neurological and metabolic diseases.
Latest Patents
Among his latest contributions, Sareen's invention involves the development of a spinal cord on a microfluidic chip. This invention relates to culturing brain endothelial cells and optionally astrocytes and neurons in a fluidic device that mimics the structure and function of the blood-brain barrier. By creating such cells in a microfluidic device, either alone or in combination with other cells, the system promotes further maturation and differentiation beyond existing methodologies.
Another significant patent focuses on the methods of use of islet cells, addressing Type 2 diabetes (T2D), which arises from insufficient insulin secretion to meet the body's needs. This invention describes compositions and methods for creating microphysiological models of disease for diabetes, allowing the comparison of chronic β-cell stimulation effects in the presence and absence of patient-specific immune cells derived from induced pluripotent stem cells (iPSCs). The islets-on-chips feature exposure to gluco-lipotoxicity, while skeletal muscle-on-chips encounter patient-specific activated immune cells, variable motor neuron innervation, and lipids characteristic of T2D.
Career Highlights
Dhruv Sareen has made significant strides in his career, having worked with notable institutions such as Cedars-Sinai Medical Center and Emulate, Inc. His innovative contributions have provided valuable insights into disease mechanisms and potential therapeutic strategies in the medical field.
Collaborations
Throughout his career, Sareen has collaborated with esteemed colleagues, including Clive N. Svendsen and Norman Wen. These partnerships have facilitated a dynamic exchange of ideas and fostered advancements in microphysiological systems and cellular modeling.
Conclusion
Dhruv Sareen continues to be a pioneering force in the realm of biomedical innovations. His patented work on microfluidic technologies not only enhances our understanding of complex diseases like Type 2 diabetes but also sets the stage for future breakthroughs in medical treatment and research. The impact of Sareen's contributions is expected to resonate within the scientific community and beyond for years to come.