The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2025
Filed:
Nov. 15, 2016
Emulate, Inc., Boston, MA (US);
Cedars-sinai Medical Center, Los Angeles, CA (US);
S.Jordan Kerns, Reading, MA (US);
Norman Wen, West Roxbury, MA (US);
Carol Lucchesi, Westwood, MA (US);
Christopher Hinojosa, Cambridge, MA (US);
Jacob Fraser, Somerville, MA (US);
Geraldine Hamilton, Cambridge, MA (US);
Gad Vatine, Los Angeles, CA (US);
Samuel Sances, Santa Monica, CA (US);
Clive Svendsen, Pacific Palisades, CA (US);
Daniel Levner, II, Brookline, MA (US);
Dhruv Sareen, Porter Ranch, CA (US);
EMULATE, INC., Boston, MA (US);
CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA (US);
Abstract
The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.