Company Filing History:
7 out of 77 
2 out of 597 
Years Active: 2021-2025
Title: Innovations by Carol Lucchesi
Introduction
Carol Lucchesi is a prominent inventor based in Westwood, MA, known for her significant contributions to the field of microfluidic devices. With a total of seven patents to her name, she has made remarkable advancements in the growth of intestinal cells and the development of brain models on microfluidic chips. Her work has the potential to revolutionize the study of various diseases, particularly those affecting the gastrointestinal and nervous systems.
Latest Patents
One of her latest patents focuses on systems and methods for the growth of intestinal cells in microfluidic devices. These organs-on-chips are designed to culture living cells in micrometer-sized chambers, effectively modeling the physiological functions of tissues and organs. The engineered patterning and continuous fluid flow in these devices enable the culturing of intestinal cells that exhibit physiologically relevant features. This innovation allows for sustained exposure to bacteria while maintaining cellular viability, facilitating the study of inflammatory bowel diseases. Additionally, her work incorporates iPSC-derived epithelium, including patient-specific cells, which enhances disease modeling by capturing the complex nature of these conditions.
Another notable patent involves the development of a spinal cord on a microfluidic chip. This invention pertains to culturing brain endothelial cells, along with astrocytes and neurons, in a fluidic device that mimics the structure and function of the blood-brain barrier. The culture of these cells in a microfluidic environment promotes maturation and differentiation beyond what existing systems can achieve.
Career Highlights
Throughout her career, Carol has worked with esteemed organizations such as Emulate, Inc. and Cedars-Sinai Medical Center. Her innovative approaches and dedication to advancing medical research have established her as a leader in her field.
Collaborations
Carol has collaborated with notable colleagues, including Norman Wen and Christopher David Hinojosa, contributing to the advancement of her research and innovations.
Conclusion
Carol Lucchesi's work in microfluidic devices and cell culture has paved the way for significant advancements in biomedical research. Her innovative patents and collaborations highlight her commitment to improving disease modeling and understanding complex biological systems.