Darmstadt, Germany

Detlef Güssow


Average Co-Inventor Count = 5.6

ph-index = 2

Forward Citations = 19(Granted Patents)


Company Filing History:


Years Active: 2005-2006

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3 patents (USPTO):Explore Patents

Title: Detlef Güssow: Innovator in Platelet Adhesion Inhibition

Introduction

Detlef Güssow is a notable inventor based in Darmstadt, Germany. He has made significant contributions to the field of biomedical research, particularly in the development of proteins that inhibit platelet adhesion. With a total of 3 patents, his work has implications for therapeutic treatments related to heart disease and circulatory system disorders.

Latest Patents

Güssow's latest patents focus on a naturally occurring protein isolated from the saliva of the medicinal leech. This protein strongly binds to collagen, acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point, and contains six cysteines. The gene for this protein was sequenced and cloned from a cDNA library. The procedures for producing this polypeptide using recombinant techniques are also disclosed in his patents. Both the recombinant and naturally occurring proteins serve as potent inhibitors of collagen-dependent platelet adhesion, making them useful for therapeutic treatments of various conditions related to heart disease and diseases of the circulatory system. Additionally, the protein can be utilized for coating natural or artificial collagen surfaces to render them nonadhesive for cells and prevent cell activation.

Career Highlights

Detlef Güssow is associated with Merck Patent GmbH, where he continues to contribute to innovative research and development in the field of biomedicine. His work has garnered attention for its potential applications in medical treatments.

Collaborations

Güssow has collaborated with notable colleagues such as Wolfgang Strittmatter and Uwe Hofmann, further enhancing the impact of his research through teamwork and shared expertise.

Conclusion

Detlef Güssow's innovative work in the field of platelet adhesion inhibition showcases the importance of research in developing therapeutic solutions for heart disease and circulatory issues. His contributions are paving the way for advancements in medical treatments.

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