The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2006
Filed:
Jun. 16, 2005
Wolfgang Strittmatter, Ober-Ramstatt, DE;
Detlef Güssow, Darmstadt, DE;
Uwe Hofmann, Alsbach, DE;
Jürgen Hemberger, Aschaffenburg, DE;
Zisi Fotev, Bickenbach, DE;
Bernhard Scheuble, Seeheim, DE;
Wolfgang Strittmatter, Ober-Ramstatt, DE;
Detlef Güssow, Darmstadt, DE;
Uwe Hofmann, Alsbach, DE;
Jürgen Hemberger, Aschaffenburg, DE;
Zisi Fotev, Bickenbach, DE;
Bernhard Scheuble, Seeheim, DE;
Merck Patent GmbH, Darmstadt, DE;
Abstract
A naturally occurring protein isolated from the saliva of the medicinal leechis described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from acDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.