Company Filing History:
Years Active: 2004-2006
Title: Zisi Fotev: Innovator in Platelet Adhesion Inhibition
Introduction
Zisi Fotev is a notable inventor based in Bickenbach, Germany. He has made significant contributions to the field of biomedical research, particularly in the development of proteins that inhibit platelet adhesion. With a total of 3 patents, his work has implications for therapeutic treatments related to heart disease and circulation disorders.
Latest Patents
One of Zisi Fotev's latest patents involves a naturally occurring protein isolated from the saliva of the medicinal leech. This protein strongly binds to collagen, acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point, and contains six cysteines. The protein was sequenced, and the gene was cloned from a cDNA library. Procedures for producing this polypeptide by recombinant techniques are disclosed in the patent. Both the recombinant and naturally occurring proteins are potent inhibitors of collagen-dependent platelet adhesion, making them useful for therapeutic treatments of various conditions related to heart disease and diseases of the circulatory system. Furthermore, the protein can be utilized for coating natural or artificial collagen surfaces to render them nonadhesive for cells and prevent cell activation.
Career Highlights
Zisi Fotev is currently associated with Merck Patent GmbH, where he continues to innovate in the field of biomedicine. His research focuses on the therapeutic applications of proteins that can significantly impact patient care and treatment outcomes.
Collaborations
Zisi has collaborated with notable colleagues such as Wolfgang Strittmatter and Uwe Hofmann, contributing to advancements in their shared field of research.
Conclusion
Zisi Fotev's work in developing proteins that inhibit platelet adhesion showcases his innovative spirit and dedication to improving medical treatments. His contributions are paving the way for new therapeutic options in the management of heart disease and related conditions.