The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2006
Filed:
Jun. 06, 2000
Maria Kordowicz, Griesheim, DE;
Detlef Gussow, Darmstadt, DE;
Uwe Hofmann, Seeheim, DE;
Tadeusz Pacuszka, Warsaw, PL;
Andrzej Gardas, Warsaw, PL;
Maria Kordowicz, Griesheim, DE;
Detlef Gussow, Darmstadt, DE;
Uwe Hofmann, Seeheim, DE;
Tadeusz Pacuszka, Warsaw, PL;
Andrzej Gardas, Warsaw, PL;
Merck Patent GmbH, Darmstadt, DE;
Abstract
The present invention relates to the isolation, purification and characterization of a hyaluronidase which derives from the tropical leech. Therefore, according to this invention, the enzyme was called 'manillase'. The invention is furthermore concerned with the recombinant method of production of manillase which includes the disclosure of DNA and amino acid sequences as well as of expression vectors and host systems. Finally, the invention relates to the use of manillase for therapeutic purposes, for example, for the treatment of myocardial diseases, thrombotic events and tumors.