Dennis R Burton

Title: Dennis R. Burton: A Pioneer in HIV Research and Antibody Development

Introduction

Dennis R. Burton, based in La Jolla, California, is a renowned inventor with an impressive portfolio of 49 patents. His work primarily focuses on the development of broadly neutralizing antibodies, particularly in the context of HIV research. Burton's innovative contributions have significantly advanced the fields of immunology and virology, providing new avenues for the prevention and treatment of HIV infections.

Latest Patents

Among Dennis R. Burton's latest patents are groundbreaking inventions aimed at combating HIV. The first, titled "Broadly neutralizing antibody and uses thereof," discusses an exceptionally broad and potent neutralizing antibody. This invention covers cross-clade neutralizing activity of 83% at a median inhibitory concentration of 0.003 μg/ml, providing compositions containing this antibody and their various uses.

Another notable patent addresses "Monoclonal antibodies directed against trimeric forms of the HIV-1 envelope glycoprotein with broad and potent neutralizing activity." This invention outlines a method for obtaining broadly neutralizing antibodies (bNabs) by screening memory B cell cultures and cloning cells exhibiting broad neutralization. The resultant monoclonal antibodies selectively bind to epitopes from the envelope proteins and inhibit the infection of HIV-1 species across various clades. Moreover, this patent includes details on generating human monoclonal anti-HIV antibodies for prophylaxis, diagnosis, and treatment of HIV infections, highlighting immunization methods using conserved epitopes.

Career Highlights

Dennis R. Burton has made significant career strides while affiliated with esteemed institutions such as The Scripps Research Institute and the International Aids Vaccine Initiative. His dedication to research and innovation has positioned him at the forefront of HIV antibody development, earning him a reputation as a leading figure in the field.

Collaborations

Throughout his career, Burton collaborated with notable colleagues, including Sanjay K. Phogat and Wayne C. Koff. These partnerships have facilitated groundbreaking research efforts, enhancing the understanding and treatment of HIV through innovative antibody technologies.

Conclusion

Dennis R. Burton's unparalleled contributions to immunology and virology through his 49 patents underscore his commitment to advancing scientific knowledge and healthcare. His work on broadly neutralizing antibodies not only broadens our understanding of HIV infection but also provides promising avenues for future treatments and preventive measures against the virus.