Company Filing History:
2 out of 443 
2 out of 1,370 
Years Active: 2025
Title: Debasish Manna: Innovator in CRISPR Technology
Introduction
Debasish Manna is a prominent inventor based in Boston, MA (US). He has made significant contributions to the field of biotechnology, particularly in the area of CRISPR technology. With a total of 2 patents, his work focuses on innovative methods and compositions that enhance genome editing capabilities.
Latest Patents
Manna's latest patents include "Methods and compositions for optochemical control of CRISPR-CAS9." This patent discloses non-naturally occurring or engineered DNA- or RNA-guided nuclease systems. These systems comprise CRISPR enzymes associated with at least one destabilization domain (DD) and photocaged stabilization ligands with at least one photocage molecule. The patent also covers compositions, systems, and complexes involving such systems, nucleic acid molecules, and vectors encoding the same, as well as delivery systems and their uses.
Another notable patent is "Targeted delivery to beta cells." This disclosure includes zinc prodrugs for the targeted delivery of therapeutic, diagnostic, or imaging agents to β-cells. It also outlines methods for the targeted delivery of small molecules that stabilize and activate CRISPR effector proteins, enabling CRISPR-based genome editing and transcriptional activation or repression in β-cells.
Career Highlights
Debasish Manna has worked with esteemed organizations such as the Broad Institute, Inc. and Brigham and Women's Hospital, Inc. His experience in these institutions has allowed him to collaborate with leading experts in the field and contribute to groundbreaking research.
Collaborations
Some of Manna's notable coworkers include Amit Choudhary and Basudeb Maji. Their collaborative efforts have further advanced the research and development of innovative biotechnological solutions.
Conclusion
Debasish Manna's contributions to CRISPR technology and biotechnology are noteworthy. His patents reflect a commitment to advancing scientific knowledge and improving therapeutic applications. His work continues to inspire future innovations in the field.
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