Location History:
- Cordova, TN (US) (1998 - 2002)
- Coralville, IA (US) (2002 - 2003)
Company Filing History:
6 out of 260 
1 out of 190 
Years Active: 1998-2003
Title: The Innovative Contributions of Dawn E Quelle
Introduction
Dawn E Quelle is a prominent inventor based in Cordova, TN (US), known for her significant contributions to the field of cell cycle regulation. With a total of 7 patents, her work has implications for cancer research and treatment.
Latest Patents
One of her latest patents, ARF-P19, focuses on a novel regulator of the mammalian cell cycle. The INK4A (MTS1, CDKN2) gene encodes a specific inhibitor, InK4a-p16, which plays a crucial role in blocking cyclin D-dependent kinases CDK4 and CDK6. This inhibition prevents the phosphorylation of the retinoblastoma protein (pRb), thereby blocking exit from the G1 phase of the cell cycle. The frequent deletions and mutations of the INK4A gene in cancer cells suggest that InK4a-p16, similar to pRb, acts as a tumor suppressor. Interestingly, an unrelated protein, ARF-p19, arises from an alternative reading frame of the mouse INK4A gene. The expression of ARF-p19 cDNA in rodent fibroblasts induces both G1 and G2 phase arrest, showcasing a unique reutilization of protein coding sequences in mammalian genomes.
Career Highlights
Dawn E Quelle has worked with esteemed institutions such as St. Jude Children's Research Hospital and Cold Spring Harbor Laboratory. Her research has significantly advanced the understanding of cell cycle control and its implications for cancer biology.
Collaborations
Some of her notable coworkers include Charles J Sherr and Martine F Roussel, who have contributed to her research endeavors.
Conclusion
Dawn E Quelle's innovative work in cell cycle regulation and her numerous patents highlight her vital role in advancing cancer research. Her contributions continue to influence the scientific community and pave the way for future discoveries.