The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 1999
Filed:
May. 25, 1994
David H Beach, Huntington Bay, NY (US);
Douglas J Demetrick, E. Northport, NY (US);
Manuel Serrano, Mill Neck, NY (US);
Gregory J Hannon, Huntington, NY (US);
Dawn E Quelle, Cordova, TN (US);
Charles J Sherr, Memphis, TN (US);
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
Abstract
The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a novel family of cell-cycle regulatory proteins ('CCR-proteins'). As described herein, these family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa (hereinafter 'p16.sup.INK4 ' OR 'p16') and which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth, and that similar to role of p21 and p53, the p16 protein may function coordinately with the cell cycle regulatory protein, retinoblastoma (Rb). Furthermore, the CCR-protein family includes a protein having an apparent molecular weight of 13.5 kDa (hereinafter 'p13.5'). The presumptive role of p13.5, like p16, is in the regulation of the cell-cycle.