Daniel T Harris

Title: The Innovations of Daniel T Harris

Introduction

Daniel T Harris is an accomplished inventor based in Urbana, IL (US). He has made significant contributions to the field of immunology, particularly in the development of engineered T cell receptors. With a total of 2 patents, his work has the potential to advance cancer therapies and improve targeted treatments.

Latest Patents

Harris's latest patents focus on engineered high-affinity human T cell receptors (TCRs). One patent describes TCRs that have specificity for the WT1 antigen. These TCRs were engineered through the generation of mutational libraries in a single-chain format, followed by selection for improved stability and affinity on the surface of yeast, a process known as directed evolution. In various applications, these TCRs can be utilized in soluble form for targeted delivery in vivo or as genes introduced into T cells in an adoptive T cell setting. Another patent highlights engineered high-affinity TCRs that target the Survivin antigen, employing a similar method of engineering to enhance their effectiveness.

Career Highlights

Harris has worked with prestigious institutions such as the University of Illinois and the Fred Hutchinson Cancer Center. His research has contributed to the understanding and development of T cell therapies, which are crucial in the fight against cancer.

Collaborations

Some of his notable coworkers include Sheena N Smith and David M Kranz. Their collaborative efforts have furthered the advancements in T cell receptor engineering.

Conclusion

Daniel T Harris is a notable inventor whose work in engineered T cell receptors is paving the way for innovative cancer treatments. His contributions to the field are significant and continue to inspire advancements in immunotherapy.