The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2019
Filed:
Nov. 21, 2014
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Sheena N. Smith, Urbana, IL (US);
Daniel T. Harris, Urbana, IL (US);
David M. Kranz, Urbana, IL (US);
Philip D. Greenberg, Seattle, WA (US);
Thomas M. Schmitt, Seattle, WA (US);
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US);
FRED HUTCHINSON CANCER RESEARCH CENTER, Seattle, WA (US);
Abstract
T cell receptors (TCRs) that have specificity for the WT1 antigen are provided. The TCRs include higher affinity TCRs that were engineered through the generation of mutational libraries of TCRs in a single-chain format, followed by selection for improved stability and affinity on the surface of yeast (i.e. directed evolution). In embodiments, the TCRs can be used in soluble form for targeted delivery in vivo, or as genes introduced into T cells in an adoptive T cell setting.