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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10023625 B1

PDFFull Text
Date of Patent:
Jul. 17, 2018

Filed:

Nov. 21, 2014

Engineered high-affinity human t cell receptors

Applicant:

The Board of Trustees of the University of Illinois, Urbana, IL (US);

Inventors:

Sheena N. Smith, Urbana, IL (US);

Daniel T. Harris, Urbana, IL (US);

David M. Kranz, Urbana, IL (US);

Assignee:

THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US);

Attorney:

Cooley LLP

Primary Examiner:

Lianko G Garyu

Assistant Examiner:

Khalid Kader

Int. Cl.
CPC ...
A61K 36/00 (2006.01); C07K 14/725 (2006.01); C07K 14/47 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); C07K 14/4747 (2013.01); A61K 38/00 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01);
Abstract

T cell receptors (TCRs) that have higher affinity for the Survivin antigen are provided. The high affinity TCRs were engineered through the generation of mutational libraries of TCRs in a single-chain format, followed by selection for improved stability and affinity on the surface of yeast (i.e. directed evolution). In embodiments, the engineered TCRs can be used in soluble form for targeted delivery in vivo, or as genes introduced into T cells in an adoptive T cell setting.

Find Patent Forward Citations

Smith, Sheena. (2018). Engineered high-affinity human t cell receptors (U.S. Patent No. 10023625). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10023625

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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