Company Filing History:
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Years Active: 1995-2010
Title: The Innovations of Daniel L Lohse
Introduction
Daniel L Lohse is a notable inventor based in Bryan, TX (US). He has made significant contributions to the field of biochemistry, particularly in the purification and characterization of heparinases. With a total of 4 patents, Lohse's work has advanced the understanding of these important enzymes.
Latest Patents
Lohse's latest patents include groundbreaking research on the purification, composition, and specificity of Heparinase I, II, and III from Flavobacterium heparinum. This patent discloses a single, reproducible scheme to simultaneously purify all three heparin lyases to apparent homogeneity. The kinetic properties of these heparin lyases have been determined, along with the conditions necessary to optimize their activity and stability. Additionally, he has developed monoclonal antibodies to the three heparinases, which are useful for their detection, isolation, and characterization. Another significant patent focuses on the purification of Heparinase I, II, and III from Flavobacterium heparinum, producing enzymes free of lyase activity, each with specific molecular weights.
Career Highlights
Lohse has worked with prestigious institutions such as the Massachusetts Institute of Technology and the University of Iowa Research Foundation. His experience in these organizations has allowed him to collaborate with leading experts in the field.
Collaborations
Some of Lohse's notable coworkers include Ramnath Sasisekharan and Charles L Cooney. Their collaborative efforts have contributed to the advancements in the study of heparinases.
Conclusion
Daniel L Lohse's innovative work in the field of biochemistry has led to significant advancements in the purification and characterization of heparinases. His contributions continue to impact the scientific community and enhance our understanding of these important enzymes.