The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 1995
Filed:
Nov. 30, 1992
Applicant:
Inventors:
Ramnath Sasisekharan, Arlington, MA (US);
Daniel L Lohse, Bryan, TX (US);
Charles L Cooney, Brookline, MA (US);
Robert J Linhardt, Iowa City, IA (US);
Robert S Langer, Newton, MA (US);
Assignees:
Massachusetts Institute of Technology, Cambridge, MA (US);
University of Iowa Research Foundation, Iowa City, IA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
435220 ; 435183 ; 435232 ; 435822 ; 435850 ;
Abstract
A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.