Daniel A Smith

Title: The Innovations of Daniel A. Smith

Introduction

Daniel A. Smith is an accomplished inventor based in Goshen, IN (US). He holds 2 patents that showcase his contributions to the field of chemistry and materials science. His work primarily focuses on texaphyrins and their applications in various technologies.

Latest Patents

Smith's latest patents include innovative developments in texaphyrin solid supports and devices. The first patent provides various novel matrix-supported texaphyrins, where a polymeric or solid matrix is covalently modified by the addition of one or more texaphyrins or texaphyrin derivatives. This invention describes methods for creating polymer-supported texaphyrins, including texaphyrin chromatographic supports and devices such as catheters. These devices can be utilized in the separation of neutral and anionic species, as well as in applications related to phosphate ester hydrolysis, catalytic schemes, MRI, and PDT.

The second patent focuses on texaphyrin metal complex-mediated ester hydrolysis. This method involves incubating a solution of an aqueous phosphate ester with a texaphyrin metal complex. The metal used is a cation with catalytic activity for ester bond hydrolysis in aqueous solutions, particularly lanthanide metal cations like Eu(III) or Dy(III). A preferred substrate for this method is RNA, and the texaphyrin used is a derivatized version that has binding specificity, particularly one that is covalently coupled to a site-directed molecule, such as an oligonucleotide.

Career Highlights

Throughout his career, Daniel A. Smith has worked with notable organizations, including Pharmacyclics, Inc. and the University of Texas System. His experience in these institutions has contributed significantly to his expertise and innovative capabilities in the field.

Collaborations

Smith has collaborated with esteemed colleagues such as Jonathan L. Sessler and Brent L. Iverson. These partnerships have likely enhanced his research and development efforts, leading to impactful inventions.

Conclusion

Daniel A. Smith's contributions to the field of texaphyrins and their applications demonstrate his innovative spirit and dedication to advancing technology. His patents reflect significant advancements that have the potential to influence various scientific and medical fields.