The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 1996
Filed:
Apr. 14, 1994
Jonathan L Sessler, Austin, TX (US);
Daniel A Smith, Goshen, IN (US);
Richard A Miller, Portola Valley, CA (US);
Kevin L Ross, Blue Ash, OH (US);
Meredith Wright, San Jose, CA (US);
William C Dow, Fremont, CA (US);
Vladimir A Kr al, Austin, TX (US);
Brent Iverson, Austin, TX (US);
Darren Magda, Cupertino, CA (US);
Board of Regents, University of Texas, Austin, TX (US);
Pharmacyclics, Inc., Sunnyvale, CA (US);
Abstract
A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a texaphyrin metal complex. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution, in particular, a lanthanide metal cation, preferably Eu(III) or Dy(III). A preferred substrate is RNA and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directed molecule, preferably an oligonucleotide.