The University of Texas System

Pharmacyclics, Inc.

Daniel A Smith

Jonathan L Sessler

Darren Magda

Brent L Iverson

Vladimir A Kr Al

Richard A Miller

Meredith Wright

Richard E Thomas

William C Dow

Kevin L Ross

The present invention provides various novel matrix-supported texaphyrins in which a polymeric or solid matrix is covalently modified by the addition of one or more texaphyrins or texaphyrin derivatives. Described are methods of making various polymer-supported texaphyrins, including texaphyrin chromatographic supports, and devices such as catheters, as may be used, for example, in the separation of neutral and anionic species and in applications concerning phosphate ester hydrolysis, other catalytic schemes, MRI, and PDT.

Texaphyrin solid supports and devices

A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a texaphyrin metal complex. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution, in particular, a lanthanide metal cation, preferably Eu(III) or Dy(III). A preferred substrate is RNA and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directed molecule, preferably an oligonucleotide.

Texaphyrin metal complex mediated ester hydrolysis

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Goshen, IN, United States of America

Daniel A Smith