Location History:
- Tuscon, AZ (US) (2021)
- Tucson, AZ (US) (2020 - 2022)
Company Filing History:
Years Active: 2020-2022
Title: Innovations by Craig A. Aspinwall
Introduction
Craig A. Aspinwall is an accomplished inventor based in Tucson, AZ. He has made significant contributions to the field of microfluidics and electrophysiology, holding a total of 3 patents. His work focuses on enhancing the performance of pneumatic valves and improving the analysis of ion channel interactions.
Latest Patents
One of his latest patents is titled "Surface-modified interfaces of pneumatic valves with enhanced electrical properties." This invention involves the creation of surface-modified glass and polymer membrane interfaces that form high-electrical resistance seals. These seals are particularly useful in microfluidic valves and array devices tailored for electrophysiological measurements. The incorporation of high seal resistance valves allows for the detection of only the desired electrophysiological signal by a patch clamp amplifier. This innovation enables parallel experiments with a single patch clamp amplifier, significantly improving cost efficiency. The valves exhibit seal resistance of >500 GΩ after modification, which is 100 times higher than that reported for unmodified valves.
Another notable patent is "Rapid conductance based ion channel analysis." This method analyzes ligand-ion channel interactions using electrophysiological techniques that offer rapid temporal response and high sensitivity. This approach reduces collection time and allows for the monitoring of dynamic processes. The protocol quantifies ligand concentrations in the sub-millisecond to millisecond range, compared to seconds to minutes for traditional methods. Furthermore, this method can be easily integrated into existing patch clamp analysis packages, facilitating the monitoring of rapid, dynamic chemical processes.
Career Highlights
Craig A. Aspinwall is affiliated with the University of Arizona, where he continues to advance research in his field. His innovative work has garnered attention and respect within the scientific community.
Collaborations
Some of his notable coworkers include Steven Scott Saavedra and Xuemin Wang, who contribute to the collaborative research efforts at the University of Arizona.
Conclusion
Craig A. Aspinwall's contributions to the fields of microfluidics and electrophysiology demonstrate his commitment to innovation and excellence. His patents reflect a deep understanding of the challenges in these areas and provide solutions that enhance research capabilities.