Company Filing History:
Years Active: 2008-2017
Title: Innovations and Contributions of Inventor Chung-Leung Chan
Introduction
Chung-Leung Chan is a notable inventor based in Sammamish, WA (US). He has made significant contributions to the field of biotechnology, particularly in the area of protein expression. With a total of 5 patents, his work has advanced the understanding and application of functional proteins in various biological systems.
Latest Patents
Among his latest patents, Chan has developed methods and materials for enhancing functional protein expression in bacteria. This innovation includes novel materials and methods useful for expressing heterologous proteins in prokaryotic cells, specifically prokaryotic cells expressing FkpA and/or Skp. Another significant patent involves the production of FGF18 in prokaryotic hosts. This patent describes expression vectors and methods utilizing an expression system for the large-scale production of FGF18. The vectors incorporate specific changes in nucleotides to optimize codons and mRNA secondary structure for translation. Using these expression vectors, the FGF18 gene was produced at levels exceeding 1 g/L in fed-batch fermentation. Additionally, the patents include OmpT deficient strains, as well as OmpT and fhuA negative strains transformed with an FGF18 expression vector.
Career Highlights
Throughout his career, Chan has worked with prominent companies in the biotechnology sector, including Zymogenetics, Inc. and Xoma Technology Ltd. His experience in these organizations has contributed to his expertise in protein expression technologies.
Collaborations
Chan has collaborated with notable colleagues such as Hong Yan Liu and Lowell J Brady. These partnerships have further enriched his research and development efforts in the field.
Conclusion
Chung-Leung Chan's innovative work in protein expression has led to significant advancements in biotechnology. His patents and collaborations reflect his commitment to enhancing functional protein production, making him a valuable contributor to the scientific community.