Chu-an Chang

Title: The Innovative Contributions of Chu-an Chang

Introduction

Chu-an Chang, a prolific inventor based in Piedmont, California, has made significant strides in the field of nucleic acid assays. With a remarkable total of 11 patents to his name, his work primarily focuses on the development of novel methodologies and sequences that enhance the capabilities of molecular diagnostics.

Latest Patents

One of his notable inventions, titled "Highly Orthogonal Universal Sequences for Use in Nucleic Acid Assays," provides a set of six-code universal sequences designed for both singleplex and multiplex bDNA assays. This invention minimizes or eliminates the undesired 3-mer cross-hybridization found in traditional bDNA assays, thereby increasing the accuracy of mRNA level determination, viral screening, SNP genotyping, and monitoring gene amplification or deletion.

Additionally, Chang holds a patent for the "Method of Generating Long Nucleic Acid Molecules of Defined Sequence." This method outlines a systematic approach to generate single-stranded nucleic acid molecules through a series of polymerase extension reactions involving competing oligonucleotides. His patented techniques greatly enhance the precision and efficiency of nucleic acid synthesis, providing valuable tools for research and diagnostics.

Career Highlights

Throughout his career, Chang has been associated with renowned organizations such as Chiron Corporation and Cetus Corporation. His efforts at these institutions have propelled forward innovations in biotechnology and molecular biology, showcasing his commitment to advancing science.

Collaborations

In his professional journey, Chang has collaborated with industry experts like Michael S. Urdea and Thomas Horn. These partnerships have enabled the exchange of ideas and collaboration on projects that enhance the scope of nucleic acid research and its applications.

Conclusion

Chu-an Chang stands out as a significant contributor to the field of molecular diagnostics with his inventive prowess. His latest patents reflect a dedication to improving the accuracy and efficiency of nucleic acid assays, making substantial impacts in both research institutions and the broader scientific community. As advancements in this field continue, Chang’s innovations are likely to play a crucial role in shaping the future of molecular diagnostics.