Christine T DeMaria

Title: Christine T DeMaria: Innovator in Biologics Production

Introduction

Christine T DeMaria is a prominent inventor based in Franklin, MA (US). She has made significant contributions to the field of biologics production, holding a total of 5 patents. Her innovative work focuses on methods for selecting and producing cells that express target polypeptides, which are crucial for large-scale manufacturing processes.

Latest Patents

Among her latest patents is the "Early post-transfection isolation of cells (EPIC) for biologics production." This patent outlines methods for selecting a population of cells that express a target polypeptide. The disclosure includes techniques for sorting and selecting transfected host cells based on their early expression of a selectable polypeptide. Notably, the sorting can be performed using fluorescence-activated cell sorting or magnetic-activated cell sorting. These selection methods are essential for generating clonal populations of producer cells for large-scale manufacturing.

Another significant patent is the "FLARE (flow cytometry attenuated reporter expression) technology for rapid bulk sorting." This patent provides methods and compositions for batch production of producer cells using fluorescence-activated cell sorting (FACS). It introduces a drug-selection-free method for batch production, which can also be utilized to generate clonal populations of producer cells for large-scale manufacturing of polypeptides.

Career Highlights

Christine has worked with notable organizations such as Genzyme Corporation and the Biochemical Institute at Christian-Albrechts University Kiel. Her experience in these institutions has contributed to her expertise in the field of biologics and cell sorting technologies.

Collaborations

Throughout her career, Christine has collaborated with esteemed colleagues, including Victor R Cairns and Jason Vitko. These collaborations have further enhanced her research and development efforts in the field.

Conclusion

Christine T DeMaria is a trailblazer in the field of biologics production, with a focus on innovative methods for cell selection and production. Her contributions through her patents and collaborations have significantly advanced the industry.