Location History:
- Singapore, SG (2014 - 2021)
- Jurong Island, SG (2022)
Company Filing History:
3 out of 1,477 
2 out of 108 
1 out of 2,405 
Years Active: 2014-2025
Title: Innovations by Charles William Johannes in Peptide Synthesis
Introduction
Charles William Johannes is a notable inventor based in Singapore, with a focus on innovations in the field of peptide synthesis. With a portfolio of four patents, his work significantly contributes to advancements in biochemical methods. His inventions aim to enhance the efficiency and utility of peptide preparation, particularly through innovative methods involving stapled peptides.
Latest Patents
Among his latest patents is the "Method of preparing stapled peptides," which details an operationally simple, one-pot solid-supported preparation technique. This method involves a ruthenium-catalysed metathesis followed by solid-phase transfer hydrogenation using triethylhydrosilane at elevated temperatures. This innovative procedure has shown promising results with 14- and 16-mer peptides, resulting in cyclic α-helix stabilized stapled peptides.
Another significant invention is the "Building blocks for stapled peptides." This patent describes a method for producing an alkenyl 1-aminocyclopropane-1-carboxylic acid featuring specific chiral centers. The method utilizes a stereoselective formation of the cyclopropane moiety through cycloaddition, which plays a crucial role in the effective production of stapled peptides.
Career Highlights
Throughout his career, Charles has worked with prominent organizations, making a marked impact in his field. Notably, he has held positions at Infinity Pharmaceuticals, Inc. and the Agency for Science, Technology and Research. His expertise and innovative methods have been influential in developing new methodologies for peptide synthesis.
Collaborations
Charles has collaborated with esteemed colleagues such as Brian C. Austad and Adilah Bahadoor. These partnerships have fostered a creative environment, allowing for the exchange of ideas and further innovations in peptide research.
Conclusion
Charles William Johannes stands out as a prolific inventor in the realm of peptide synthesis. His contributions, captured in his patents, reflect a deep understanding of biochemical processes and a commitment to advancing the effectiveness of peptide preparation methods. With continued research and collaboration, his work promises to foster further innovations in the field.