The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2021
Filed:
Mar. 23, 2018
Applicant:
Agency for Science, Technology and Research, Singapore, SG;
Inventors:
Tsz Ying Yuen, Singapore, SG;
Charles William Johannes, Singapore, SG;
Greg Verdine, Cambridge, MA (US);
Assignee:
Agency for Science, Technology and Research, Singapore, SG;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 227/12 (2006.01); C07C 229/48 (2006.01); C07D 265/32 (2006.01); C07D 265/34 (2006.01); C07K 5/08 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
C07C 227/12 (2013.01); C07C 229/48 (2013.01); C07D 265/32 (2013.01); C07D 265/34 (2013.01); C07K 5/0802 (2013.01); C07K 7/06 (2013.01); C07C 2601/02 (2017.05);
Abstract
This invention relates to a method for producing an alkenyl 1-aminocyclopropane-1-carboxylic acid of Formula I wherein Ris a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B is R and when A is R, B is S. The method comprises a stereoselective formation of the cyclopropane moiety by cycloaddition onto a double bond, in a molecule comprising a chiral template, Formula lc. Further provided is the use of Formula I in the production of stapled peptides.