The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Jul. 31, 2018
Applicant:
Agency for Science, Technology and Research, Singapore, SG;
Inventors:
Tsz Ying Yuen, Jurong Island, SG;
Charles William Johannes, Jurong Island, SG;
Gerard Hilinski, Somerville, MA (US);
Assignee:
Agency for Science, Technology and Research, Singapore, SG;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/08 (2006.01); C01G 55/00 (2006.01); C07K 1/04 (2006.01); C07K 1/12 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); C01G 55/00 (2013.01); C07K 1/045 (2013.01); C07K 1/12 (2013.01);
Abstract
Described herein is an operationally simple, one-pot solid-supported preparation of saturated stapled peptides. Following completion of ruthenium-catalysed metathesis, solid-phase transfer hydrogenation was achieved using triethylhydrosilane at elevated temperatures. The utility of the method has been demonstrated on 14- and 16-mer peptides to yield the corresponding cyclic a-helix stabilised stapled peptides.