Charles M Wittmer

Title: Inventor Charles M. Wittmer: Innovator in Thermal Cycler Technology

Introduction

Charles M. Wittmer, located in Trumbull, CT, is a distinguished inventor with a notable portfolio of 12 patents. His contributions to the field of biotechnology have made a significant impact, particularly with his advancements in temperature control instruments used in Polymerase Chain Reaction (PCR) processes.

Latest Patents

Wittmer’s latest innovation, a thermal cycler for PCR, represents a breakthrough in performing highly accurate PCR. This sophisticated instrument incorporates an assembly, a heated cover, and an internal computer to enhance performance. The assembly consists of a sample block and multiple Peltier thermal electric devices, as well as a heat sink, all clamped together to optimize functionality. A unique control algorithm manipulates the current supplied to the thermoelectric coolers, allowing for dynamic thermal performance adjustment. This enables the ability to execute pre-defined thermal profiles with precision, calculated through a design-specific model rather than measured directly.

The thermal cycler features a sample block constructed from low thermal mass silver, designed to offer rapid temperature changes across a wide range. To ensure consistency, the heat sink includes a perimeter trench to minimize edge losses and is complemented by a continuously variable fan. Moreover, a heated platen applies the necessary force to ensure optimal thermal contact with sample tubes, preventing evaporation and distortion during thermal cycling. Wittmer’s device incorporates a graphical user interface and advanced monitoring systems that alert users to potential failures, ensuring reliability and precision across various instruments.

Career Highlights

Wittmer has made significant strides in his career, particularly with his work at Applied Biosystems, LLC and The Perkin-Elmer Corporation. His expertise in thermal cycling technology has positioned him as a pioneer in his field, contributing to the efficiency and accuracy of biological research processes.

Collaborations

Throughout his career, Charles M. Wittmer has collaborated with notable figures such as John Girdner Atwood and Adrian Fawcett. These partnerships have further enriched his work and fostered innovations within the biotechnology sector.

Conclusion

With his remarkable contributions and innovative patents, Charles M. Wittmer stands out as a prominent inventor in the realms of biotechnology and thermal cycling technologies. His advancements continue to benefit research institutions and companies alike, showcasing the vital role of innovation in scientific progress.