The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2017
Filed:
Aug. 22, 2008
John G. Atwood, West Redding, CT (US);
Adrian Fawcett, Pleasanton, CA (US);
Keith S. Ferrara, Stratford, CT (US);
Paul M. Hetherington, Goldens Bridge, NY (US);
Richard W. Noreiks, Stratford, CT (US);
Douglas E. Olsen, New Fairfield, CT (US);
John R. Widomski, Shelton, CT (US);
Charles M. Wittmer, Trumbull, CT (US);
John G. Atwood, West Redding, CT (US);
Adrian Fawcett, Pleasanton, CA (US);
Keith S. Ferrara, Stratford, CT (US);
Paul M. Hetherington, Goldens Bridge, NY (US);
Richard W. Noreiks, Stratford, CT (US);
Douglas E. Olsen, New Fairfield, CT (US);
John R. Widomski, Shelton, CT (US);
Charles M. Wittmer, Trumbull, CT (US);
APPLIED BIOSYSTEMS, LLC, Carlsbad, CA (US);
Abstract
An instrument for performing highly accurate PCR employing an assembly, a heated cover, and an internal computer, is provided. The assembly is made up of a sample block, a number of Peltier thermal electric devices, and a heat sink, clamped together. A control algorithm manipulates the current supplied to thermoelectric coolers such that the dynamic thermal performance of a block can be controlled so that pre-defined thermal profiles of sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics.