Charles A Thornton

Title: Innovations and Contributions of Charles A. Thornton

Introduction

Charles A. Thornton is a notable inventor based in Rochester, NY (US). He has made significant contributions to the field of molecular biology, particularly in the study and treatment of myotonic dystrophy. With a total of 4 patents, his work has paved the way for advancements in therapeutic methods.

Latest Patents

Thornton's latest patents include groundbreaking methods for modulating dystrophia myotonica-protein kinase (DMPK) expression. These patents provide methods, compounds, and compositions aimed at reducing the expression of DMPK mRNA and protein in animals. Additionally, they focus on preferentially reducing CUGexp DMPK RNA, which is crucial for treating type 1 myotonic dystrophy and its symptoms. Another significant patent involves compositions and methods related to protein displacement therapy for myotonic dystrophy. This patent discloses methods for treating DM1 or DM2 by inhibiting the interaction of poly(CUG) or poly(CCUG) RNA with muscleblind proteins, thereby improving spliceopathy in myotonic dystrophy.

Career Highlights

Throughout his career, Thornton has worked with esteemed institutions such as the University of Rochester and Ionis Pharmaceuticals, Inc. His research has been instrumental in developing innovative approaches to address genetic disorders.

Collaborations

Thornton has collaborated with notable colleagues, including Thurman Wheeler and Krzysztof Sobczak. Their combined expertise has contributed to the advancement of research in the field of myotonic dystrophy.

Conclusion

Charles A. Thornton's contributions to the field of molecular biology and his innovative patents have significantly impacted the understanding and treatment of myotonic dystrophy. His work continues to inspire future research and development in this critical area of health.