The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Jul. 30, 2015
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
University of Rochester, Rochester, NY (US);
C. Frank Bennett, Carlsbad, CA (US);
Susan M. Freier, San Diego, CA (US);
Robert A. MacLeod, San Diego, CA (US);
Sanjay K. Pandey, Encinitas, CA (US);
Charles A. Thornton, Rochester, NY (US);
Thurman Wheeler, Rochester, NY (US);
Seng H. Cheng, Natick, MA (US);
Andrew Leger, Boston, MA (US);
Bruce M. Wentworth, Northborough, MA (US);
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.