The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Jun. 05, 2014
Applicants:
University of Rochester, Rochester, NY (US);
University of Florida Research Foundation, Inc., Gainsville, FL (US);
Inventors:
Charles A. Thornton, Rochester, NY (US);
Thurman Wheeler, Rochester, NY (US);
Krzysztof Sobczak, Poznan, PL;
Robert Osborne, Essex, GB;
Jill Miller, Rockport, NY (US);
Maurice Scott Swanson, Gainsville, FL (US);
Assignee:
University of Rochester, Rochester, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); A61K 38/14 (2006.01); A61K 31/7088 (2006.01); C12N 5/00 (2006.01); C12N 15/113 (2010.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01); A61K 31/5375 (2006.01); A61K 31/7036 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/5375 (2013.01); A61K 31/7036 (2013.01); A61K 47/48046 (2013.01); C12Y 207/11001 (2013.01); G01N 33/5008 (2013.01); G01N 33/6872 (2013.01); G01N 33/6887 (2013.01); G01N 33/6893 (2013.01); C12N 2310/11 (2013.01); C12N 2310/3233 (2013.01); C12N 2310/3515 (2013.01); G01N 2500/02 (2013.01); G01N 2800/2878 (2013.01);
Abstract
Disclosed are compositions and methods related to the interaction of polyCUG and polyCCUG repeat RNA and proteins that bind to these repetitive RNA sequences. Also disclosed are methods of treating DM1 or DM2 comprising inhibiting the interaction of poly(CUG)or poly(CCUG)RNA with muscleblind proteins, or by causing improvement of spliceopathy in myotonic dystrophy.