The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2015
Filed:
Jul. 28, 2008
Benjamin L. Miller, Penfield, NY (US);
Brian R. Mcnaughton, Rochester, NY (US);
Peter C. Gareiss, Rochester, NY (US);
Joseph Wedekind, Rochester, NY (US);
Charles Thornton, Rochester, NY (US);
Krzysztof Sobczak, Poznan, PL;
Benjamin L. Miller, Penfield, NY (US);
Brian R. McNaughton, Rochester, NY (US);
Peter C. Gareiss, Rochester, NY (US);
Joseph Wedekind, Rochester, NY (US);
Charles Thornton, Rochester, NY (US);
Krzysztof Sobczak, Poznan, PL;
University of Rochester, Rochester, NY (US);
Abstract
The present invention relates to homo- and hetero-dimer compounds formed by a disulfide, sulfinyl thio, or olefin bond between two monomers. A method of making a homo- or hetero-dimer compound is also disclosed. The present invention also relates to monomer compounds capable of forming homo- or hetero-dimer compounds, as well as oligomers formed via linkage of one or more dimers. Also disclosed are methods of inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-I RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules. The dimer compounds can also be used for selectively detecting presence of the target RNA molecule in a sample.