Charlene Ching

Title: Innovator Spotlight: Charlene Ching

Introduction

Charlene Ching, based in San Jose, California, is a prolific inventor with a remarkable portfolio of 19 patents. Her innovations are primarily focused on biochemistry, particularly in the engineering of enzymes to facilitate complex chemical reactions.

Latest Patents

Charlene's latest patents include groundbreaking work on engineered imine reductases and engineered glucose dehydrogenases. The first patent describes engineered polypeptides with imine reductase activity, which are designed for the reductive amination of ketone and amine compounds. This innovation presents polynucleotides that encode these engineered polypeptides, as well as host cells capable of expressing them. The methods outlined in this patent contribute to the preparation of secondary and tertiary amine product compounds from a variety of substrates.

Her second patent concerning engineered glucose dehydrogenases also targets the same reductive amination processes, showcasing similar applications and methodologies to produce amine compounds. These contributions are vital in the fields of pharmaceuticals and industrial biochemistry, where precise chemical transformations are crucial.

Career Highlights

Charlene Ching has made significant strides in her career, having worked with leading organizations such as Codexis, Inc. and Pfizer Corporation. Her contributions in these institutions have not only furthered her expertise but also fostered advancements in the biotechnological domain.

Collaborations

Throughout her career, Charlene has collaborated with renowned colleagues, including John M Gruber and Emily Mundorff. These partnerships have enabled her to share knowledge and expand the potential applications of her inventions, advancing both her work and the capabilities of her teams.

Conclusion

Charlene Ching's innovative spirit and dedication to her field have solidified her reputation as a leading inventor. With her extensive patent portfolio and impactful collaborations, she continues to contribute significantly to the scientific community, particularly in the development of advanced biochemical solutions.