Codexis, Inc.

Pfizer Corporation

Charlene Ching

Emily Mundorff

Gjalt W Huisman

John M Gruber

Stephane J Jenne

Anke Krebber

Jack S Liang

Lisa Marie Newman

David Entwistle

Ravi David Garcia

Oscar Alvizo

Nikki Dellas

Scott J Novick

James Nicholas Riggins

Xiang Yi

Vesna Mitchell

Louis Clark

Dipnath Baidyaroy

Nandhitha Subramanian

Gjalt W Hiusman

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

Ketoreductase polypeptides for the reduction of acetophenones

The present invention provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The invention also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.

Engineered transaminase polypeptides for industrial biocatalysis

The present application provides engineered glucose dehydrogenase polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds

The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides. Methods for producing PAL enzymes are also provided. In some embodiments, the engineered PAL polypeptides are optimized to provide enhanced catalytic activities that are useful under industrial process conditions for the production of pharmaceutical compounds.

Engineered phenylalanine ammonia lyase polypeptides

Polynucleotides encoding ketoreductase polypeptides for reduction of acetophenones

Methods of using ketoreductase polypeptides for reduction of acetophenones

Ketoreductases and uses thereof

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San Jose, CA, United States of America

Charlene Ching