Company Filing History:
Years Active: 2024-2025
Title: The Innovative Contributions of Carrie M Margulies
Introduction
Carrie M Margulies is a prominent inventor based in Waban, Massachusetts. She has made significant contributions to the field of genetic research, particularly in the development of innovative therapies for genetic disorders. With a total of three patents to her name, Margulies has established herself as a key figure in the biotechnology industry.
Latest Patents
Margulies' latest patents include groundbreaking work in the treatment of genetic conditions. One of her notable patents is the "CRISPR/Cas9-mediated exon-skipping approach for USH2A-associated usher syndrome." This invention focuses on compositions for treating subjects with USH2A-associated retinal and/or cochlear degeneration caused by mutations in exon 13 of the USH2A gene. The method involves the deletion of exon 13 from the USH2A gene or its transcripts, along with the development of genetically modified animals and cells for research purposes. Another significant patent is for "Systems and methods for treating hyper-igm syndrome." This invention discloses genome editing systems and related methods that enable the treatment of Hyper IgM Syndrome, characterized by defective CD40 signaling. The compositions and methods rely on donor templates comprising CD40L exons to restore proper CD40 signaling and facilitate B cell class switch recombination.
Career Highlights
Throughout her career, Margulies has worked with leading organizations in the biotechnology sector. She has been associated with Editas Medicine, Inc., a company known for its pioneering work in genome editing. Additionally, she has contributed her expertise at the Massachusetts Eye and Ear Infirmary, where she has focused on advancing research in ocular and auditory disorders.
Collaborations
Margulies has collaborated with notable professionals in her field, including Cecillia Cotta-Ramusino and Luigi Naldini. These collaborations have further enhanced her research and development efforts, leading to innovative solutions for complex genetic issues.
Conclusion
Carrie M Margulies is a trailblazer in the field of genetic research, with her patents reflecting her commitment to advancing medical science. Her work continues to inspire future innovations in the treatment of genetic disorders.