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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12214055 B1

PDFFull Text
Date of Patent:
Feb. 04, 2025

Filed:

Oct. 24, 2018

Systems and methods for treating hyper-igm syndrome

Applicants:

Editas Medicine, Inc., Cambridge, MA (US);

Fondazione Telethon Ets, Rome, IT;

Ospedale San Raffaele, Milan, IT;

Inventors:

Cecillia Cotta-Ramusino, Cambridge, MA (US);

Carrie M. Margulies, Waban, MA (US);

Luigi Naldini, Milan, IT;

Pietro Genovese, Milan, IT;

Assignee:

EDITAS MEDICINE INC., CAMBRIDGE, US;

Attorney:

McDonnell Boehnen Hulbert & Berghoff

Primary Examiner:

Allison M Fox

Assistant Examiner:

Qinhua Gu

Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 39/00 (2006.01); A61P 37/02 (2006.01); C07K 14/475 (2006.01); C07K 14/705 (2006.01); C12N 15/10 (2006.01); C12N 15/113 (2010.01); C12N 15/86 (2006.01); C12N 15/90 (2006.01); A61K 35/17 (2015.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 39/461 (2023.05); A61K 39/4611 (2023.05); A61K 39/464411 (2023.05); A61P 37/02 (2018.01); C07K 14/475 (2013.01); C07K 14/70575 (2013.01); C07K 14/70578 (2013.01); C12N 15/102 (2013.01); C12N 15/113 (2013.01); C12N 15/86 (2013.01); C12N 15/907 (2013.01); C12N 2750/14143 (2013.01); C12N 2830/50 (2013.01); C12N 2840/203 (2013.01);
Abstract

Disclosed herein are genome editing systems and related methods which allow for treatment of Hyper IgM Syndrome, a group of disorders characterized by defective CD40 signaling. The compositions and methods described herein rely on the use of donor templates comprising a CD40L exons to restore proper CD40 signaling and B cell class switch recombination.

Find Patent Forward Citations

Cotta-Ramusino, Cecillia. (2025). Systems and methods for treating hyper-igm syndrome (U.S. Patent No. 12214055). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12214055

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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