Carol M Kinoshita

Title: Carol M Kinoshita: Innovator in Protein Production

Introduction

Carol M Kinoshita is a prominent inventor based in Bedford, MA (US). She has made significant contributions to the field of biotechnology, particularly in the production of high mannose proteins. With a total of 6 patents to her name, Kinoshita's work has advanced the understanding and application of glucocerebrosidase.

Latest Patents

One of her latest patents focuses on high mannose proteins and methods of making them. This invention features a method for producing a high mannose glucocerebrosidase (hmGCB). The process involves providing a cell capable of expressing glucocerebrosidase (GCB) and allowing the production of GCB with a precursor oligosaccharide. This is done under conditions that prevent the removal of at least one mannose residue distal to the pentasaccharide core of the precursor oligosaccharide. The invention also includes an hmGCB preparation and methods for its use. Another notable patent involves nucleic acid encoding a chimeric polypeptide, which comprises DNA molecules that encode the signal peptide of human growth hormone linked to a heterologous protein.

Career Highlights

Throughout her career, Kinoshita has worked with several notable companies, including Transkaryotic Therapies, Inc. and Shire Human Genetic Therapies, Inc. Her innovative work has positioned her as a key figure in the biotechnology sector.

Collaborations

Kinoshita has collaborated with esteemed colleagues such as Marianne Borowski and Richard F Selden. These partnerships have further enhanced her research and contributions to the field.

Conclusion

Carol M Kinoshita's work in the development of high mannose proteins and her numerous patents highlight her significant impact on biotechnology. Her innovative approaches continue to influence the industry and pave the way for future advancements.