Location History:
- Durham, NC (US) (2013 - 2022)
- Chapel Hill, NC (US) (2023)
Company Filing History:
10 out of 1,270 
2 out of 15,458 
2 out of 5,303 
Years Active: 2013-2025
Title: The Innovative Mind of Bryan Leo Roth
Introduction
Bryan Leo Roth, an esteemed inventor based in Durham, NC, has made significant contributions to the field of pharmaceutical sciences, particularly through his pioneering work on G protein-coupled receptors (GPCRs). With a remarkable portfolio of 11 patents, his research has the potential to revolutionize pain management therapies.
Latest Patents
Roth's latest patents include groundbreaking advancements in GPCR assay platforms. One of his notable inventions is the G protein-coupled receptor screening systems, which consists of two complementary methods designed to replicate the dynamic interactions between receptors and transducers in living cells. The in vitro ADSoRB method forces the dissociation of transducers from receptors, thereby altering receptor conformations and simulating pathway activation within a cell. Another innovation, the TRUPATH method, focuses on measuring the dissociation of engineered G protein heterotrimer complexes to achieve single transducer resolution in cellular environments.
Another significant patent involves G-protein biased opioid receptor agonists and analgesics that are designed to reduce arrestin recruitment. These compounds present an innovative solution for pain relief, offering an improved pharmaceutical profile when compared to traditional opiates and opioid derivatives.
Career Highlights
Roth has had an influential academic career, including positions at notable institutions such as the University of North Carolina at Chapel Hill and the University of California. His work has garnered attention for not only its scientific merit but also its practical applications in targeted pain management therapies.
Collaborations
Throughout his career, Roth has collaborated with prominent researchers in his field, including Brian K. Shoichet and Henry Lin. These partnerships have facilitated valuable exchanges of ideas and have contributed to the advancement of research in GPCR pharmacology.
Conclusion
Bryan Leo Roth's innovative contributions to the field of receptor pharmacology exemplify the role of inventors in transforming medical research into practical solutions. With his extensive patent portfolio and collaborative efforts, Roth continues to pave the way for future advancements in pain management and therapeutic development.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.