The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
Jun. 22, 2017
Applicant:
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Inventors:
Benjamin David Philpot, Durham, NC (US);
Mark John Zylka, Chapel Hill, NC (US);
Bryan Leo Roth, Durham, NC (US);
John Arthur Allen, North Billerica, MA (US);
Hsien-Sung Huang, Kaohsiung, TW;
Assignee:
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/473 (2006.01); A61K 31/496 (2006.01); C12N 15/63 (2006.01); A61K 31/713 (2006.01); A61K 31/4741 (2006.01); A61K 31/4745 (2006.01); A61K 31/5377 (2006.01); A61K 31/7048 (2006.01); A61K 31/7105 (2006.01);
U.S. Cl.
CPC ...
C12N 15/635 (2013.01); A61K 31/473 (2013.01); A61K 31/4741 (2013.01); A61K 31/4745 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/7048 (2013.01); A61K 31/713 (2013.01); A61K 31/7105 (2013.01);
Abstract
The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.