The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 28, 2023

Filed:

Jul. 08, 2020
Applicants:

University of Health Sciences & Pharmacy IN St. Louis, St. Louis, MO (US);

University of Southern California, Los Angeles, CA (US);

The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);

Memorial Sloan Kettering Cancer Center, New York, NY (US);

University of Florida Research Foundation, Incorporated, Gainesville, FL (US);

Memorial Sloan Kettering Cancer Center, New York, NY (US);

Inventors:

Susruta Majumdar, St. Louis, MO (US);

Vsevolod Katritch, Los Angeles, CA (US);

Bryan Roth, Chapel Hill, NC (US);

Jay McLaughlin, Gainesville, FL (US);

Saheem Zaidi, Los Angeles, CA (US);

Gavril W. Pasternak;

Rajendra Uprety, Cary, NC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 489/00 (2006.01); C07D 221/28 (2006.01);
U.S. Cl.
CPC ...
C07D 489/00 (2013.01); C07D 221/28 (2013.01);
Abstract

In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.


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