Company Filing History:
4 out of 2,012 
3 out of 3,540 
Years Active: 2014-2018
Title: Innovator Bryan Daehahn Choi: Pioneering Therapeutic Antibody Technologies
Introduction: Bryan Daehahn Choi is an accomplished inventor based in Durham, North Carolina. With a total of four patents to his name, Choi has made significant contributions to the field of biotherapeutics, particularly through his innovative work on bispecific antibodies that target specific cancer cells.
Latest Patents: Choi's recent patents include groundbreaking developments in human bispecific EGFRvIII and CD3 antibody engaging molecules. These patents describe the construction of polynucleotides that encode bispecific antibody engaging molecules. One arm of these molecules specifically targets tumor cells expressing the human EGFRvIII mutant protein, while the other arm engages the T cell activation ligand CD3. The polynucleotides are codon-optimized for expression in Chinese Hamster Ovary (CHO) cells, which allows for greater efficacy in therapeutic applications. Additionally, the engaging molecules developed by Choi are not only highly cytotoxic but also antigen-specific, making them suitable for therapeutic use against cancers expressing the EGFRvIII mutation.
Career Highlights: Throughout his career, Bryan Daehahn Choi has worked with renowned institutions, notably Duke University and the United States Department of Health and Human Services. His work has significantly advanced the possibilities within the realm of targeted cancer therapies.
Collaborations: Choi has collaborated with esteemed colleagues including John Howard Sampson and Darell D Bigner. These collaborations have played a crucial role in enhancing the development and application of his innovative antibody technologies.
Conclusion: Bryan Daehahn Choi exemplifies the spirit of innovation in the field of biotherapeutics. His patents on bispecific antibodies highlight his commitment to developing more effective treatment options for cancer patients. As research continues to evolve, Choi's contributions stand to make a lasting impact on cancer therapy and patient care.