The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2016
Filed:
Nov. 15, 2011
Darell D. Bigner, Mebane, NC (US);
Chien-tsun Kuan, Cary, NC (US);
John H. Sampson, Durham, NC (US);
Mingqing Cai, Danbury, CT (US);
Bryan D. Choi, Durham, NC (US);
Ira H. Pastan, Potomac, MD (US);
Darell D. Bigner, Mebane, NC (US);
Chien-Tsun Kuan, Cary, NC (US);
John H. Sampson, Durham, NC (US);
Mingqing Cai, Danbury, CT (US);
Bryan D. Choi, Durham, NC (US);
Ira H. Pastan, Potomac, MD (US);
Secretary, DHHS, Rockville, MD (US);
Duke University, Durham, NC (US);
Abstract
We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging molecules are highly cytotoxic and antigen-specific.