The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2018
Filed:
Jul. 09, 2014
Duke University, Durham, NC (US);
The United States of America As Represented BY the Secretary of Health and Human Services, National Institutes of Health, Washington, DC (US);
Darell D. Bigner, Mebane, NC (US);
John Sampson, Durham, NC (US);
Chien-Tsun Kuan, Cary, NC (US);
Mingqing Cai, Durham, NC (US);
Bryan D. Choi, Durham, NC (US);
Patrick C. Gedeon, Durham, NC (US);
Ira H. Pastan, Potomac, MD (US);
Duke University, Durham, NC (US);
The United States of America as Represented by the Secretary of Health and Human Services, National Institutes of Health, Washington, DC (US);
Abstract
We have constructed a polynucleotide encoding a bispecific antibody engaging molecule which has one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The polynucleotide is codon optimized for expression in CHO cells. The subunits of the engaging molecules are organized to achieve greater efficiency. These are therapeutic agents.