Company Filing History:
Years Active: 1995-1997
Title: Bruce L Roth: Innovator in Fluorescent Dyes
Introduction
Bruce L Roth is a notable inventor based in Corvallis, OR (US). He has made significant contributions to the field of fluorescent dyes, holding a total of 5 patents. His work has advanced the analysis of nucleic acids and bacterial identification, showcasing his expertise in innovative chemical solutions.
Latest Patents
One of Roth's latest patents is for "Substituted unsymmetrical cyanine dyes with selected permeability." This invention describes the preparation and use of fluorescent stains for nucleic acids derived from unsymmetrical cyanine dyes. The dyes comprise a substituted benzazolium ring system linked by a methine bridge to a pyridinium or quinolinium ring system. The presence of a heteroatom-containing substituent enhances sensitivity to oligonucleotides and larger nucleic acid polymers across various cells and gels. This innovation is particularly useful for analyzing cell structure, membrane integrity, or function.
Another significant patent is the "Fluorescent assay for bacterial gram reaction." This invention relates to a method of analyzing samples suspected of containing bacteria using an aqueous solution with multiple fluorescent dyes. Each dye has a unique affinity for nucleic acids and responds differently to various types of bacteria. The method allows for the differentiation of live and dead Gram-positive and Gram-negative bacteria, providing a powerful tool for microbiological analysis.
Career Highlights
Bruce L Roth has established himself as a key figure in the field of fluorescent dye technology. His work at Molecular Probes, Inc. has been instrumental in developing innovative solutions for biological research and diagnostics. His patents reflect a deep understanding of chemical interactions and their applications in real-world scenarios.
Collaborations
Roth has collaborated with notable colleagues such as Stephen T Yue and Paul J Millard. These partnerships have contributed to the advancement of research and development in the field of fluorescent dyes.
Conclusion
Bruce L Roth's contributions to the field of fluorescent dyes have significantly impacted biological research and diagnostics. His innovative patents demonstrate his commitment to advancing scientific knowledge and technology.