Bruce L Grasberger

Title: Bruce L Grasberger: Innovator in Protein Engineering

Introduction

Bruce L Grasberger is a notable inventor based in Trappe, PA (US), recognized for his contributions to the field of protein engineering. He holds a total of five patents, showcasing his innovative approach to scientific challenges.

Latest Patents

Grasberger's latest patents focus on the engineering of monoacylglycerol lipase (MGLL). His work includes the development of several soluble engineered forms of MGLL that are suitable for high-throughput screening and protein crystallization. These patents disclose a crystallized form of MGLL and detailed descriptions of the X-ray diffraction patterns. The engineered constructs allow for the expression and purification of proteins that are ideal for crystallography or high-throughput screening. This enables the identification of ligands that can act as active agents to MGLL. The X-ray diffraction patterns facilitate the determination of MGLL's three-dimensional structure at atomic resolution, allowing for the identification of ligand binding sites and modeling of interactions with MGLL amino acid residues. Such models aid in designing ligands that can function as active agents, including inhibitors of MGLL.

Career Highlights

Throughout his career, Bruce L Grasberger has worked with prominent companies, including Janssen Pharmaceutica NV. His expertise in protein engineering has significantly contributed to advancements in the pharmaceutical industry.

Collaborations

Grasberger has collaborated with notable colleagues, including Celine Schalk-Hihi and Diane M Maguire, enhancing the impact of his research through teamwork and shared expertise.

Conclusion

Bruce L Grasberger's innovative work in protein engineering, particularly with monoacylglycerol lipase, highlights his significant contributions to science and technology. His patents reflect a commitment to advancing our understanding of protein interactions and their potential applications in medicine.