The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2011
Filed:
Apr. 23, 2010
Carsten Schubert, Exton, PA (US);
Bruce Grasberger, Trappe, PA (US);
Diane Maguire, Downington, PA (US);
Ingrid Deckman, Berwyn, PA (US);
John Spurlino, Downington, PA (US);
Carsten Schubert, Exton, PA (US);
Bruce Grasberger, Trappe, PA (US);
Diane Maguire, Downington, PA (US);
Ingrid Deckman, Berwyn, PA (US);
John Spurlino, Downington, PA (US);
Ortho-McNeil Pharmaceutical, Inc., Raritan, NJ (US);
Abstract
The present invention includes crystallized HDM2 peptides as well as descriptions of the X-ray diffraction patterns of the crystals. The diffraction patterns allow the three dimensional structure of HDM2 to be determined at atomic resolution so that ligand binding sites on HDM2 can be identified and the interactions of ligands with HDM2 amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of MDM2 and HDM2 oncoproteins.