Location History:
- Columbus Junction, IA (US) (2017)
- Olney, MD (US) (2009 - 2018)
- Smyrna, GA (US) (2010 - 2020)
- Davenport, IA (US) (2012 - 2023)
Company Filing History:
6 out of 45 
3 out of 168 
2 out of 51 
Years Active: 2009-2023
Title: Innovations of Inventor Brian Lowe
Introduction
Brian Lowe, based in Olney, MD, is a remarkable inventor known for his contributions to the field of genetic research and diagnostics. With a total of seven patents to his name, his work primarily focuses on the detection of HPV and the analysis of RNA splice-forms, which are crucial in understanding precancerous conditions in cervical tissues.
Latest Patents
Among Brian Lowe's latest patents are two significant innovations:
1. **Materials and methods for detection of HPV nucleic acids** – This patent provides nucleic acids that are capable of hybridizing to HPV 16 and/or HPV 18 nucleic acids, particularly mRNA encoding E2 and E6-7 gene products. These nucleic acids are instrumental in isolating RNA from biological samples, determining the presence of specific RNA splice-form variants, analyzing RNA ratios, predicting the progression of precancerous cervical lesions, and detecting disruptions in genes or gene expression.
2. **Non-target amplification method for detection of RNA splice-forms in a sample** – This invention outlines methods for isolating RNA from biological samples and determining the presence of particular RNA splice-form variants. It also addresses the assessment of RNA ratios and the prediction of the progression of precancerous cervical lesions.
Career Highlights
Brian has had an impressive career, having worked with notable organizations such as Qiagen Gaithersburg Inc. His experience in advanced genetic research and diagnostics has significantly shaped his inventive journey, leading him to develop impactful technologies aimed at improving health outcomes.
Collaborations
Throughout his career, Brian Lowe has collaborated with esteemed colleagues like Irina A Nazarenko and Attila T Lorincz. These partnerships have enhanced his research and broadened the scope of his innovations, allowing him to tackle complex challenges in the field of molecular diagnostics.
Conclusion
With a dedicated focus on HPV detection and RNA analysis, Brian Lowe continues to make significant contributions to medical research and innovation. His patents not only advance scientific understanding but also provide essential tools for early diagnosis and treatment of cervical lesions, showcasing the importance of invention in improving public health.