Company Filing History:
5 out of 4,125 
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1 out of 832,843 Years Active: 1997-2014
Title: Brian L Frey: Innovator in Protein Sequencing Technologies
Introduction
Brian L Frey is a notable inventor based in Madison, WI (US), recognized for his contributions to the field of protein and peptide sequencing. With a total of 6 patents to his name, Frey has developed innovative methods that enhance the analysis of proteins, which are crucial for various applications in biotechnology and medicine.
Latest Patents
Frey's latest patents include groundbreaking techniques such as "Protein/peptide sequencing by chemical degradation in the gas phase." This invention presents a fast and sensitive method for sequencing proteins and polypeptides by utilizing a combination of Edman degradation chemistry and mass spectrometry. The method involves performing a peptide degradation reaction on a polypeptide or protein ion reactant in the gas phase, yielding ion products that correspond to specific amino acid residues. The mass-to-charge ratio of these products is then determined to identify the first amino acid residue of the protein or polypeptide.
Another significant patent is "Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis." This invention enhances peptide fragmentation for mass spectrometry by modifying peptides with tagging reagents that contain functional groups with higher gas-phase basicity than the peptide's amide backbone. This modification leads to higher charge state ions from electrospray ionization mass spectrometry (ESI-MS), which fragment more extensively during advanced fragmentation techniques.
Career Highlights
Throughout his career, Brian L Frey has worked with the Wisconsin Alumni Research Foundation, where he has contributed to various research initiatives. His work has significantly impacted the field of mass spectrometry and protein analysis, making him a key figure in the scientific community.
Collaborations
Frey has collaborated with notable colleagues such as Lloyd M Smith and Joshua J Coon, further enhancing the scope and impact of his research in protein sequencing technologies.
Conclusion
Brian L Frey's innovative work in protein and peptide sequencing has paved the way for advancements in mass spectrometry and biotechnology. His contributions continue to influence the field, showcasing the importance of innovation in scientific research.