The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2014
Filed:
Jul. 15, 2005
Xiaoyu Chen, Westlake Village, CA (US);
Michael S. Westphall, Fitchburg, WI (US);
Lloyd M. Smith, Madison, WI (US);
Brian L. Frey, Madison, WI (US);
Xiaoyu Chen, Westlake Village, CA (US);
Michael S. Westphall, Fitchburg, WI (US);
Lloyd M. Smith, Madison, WI (US);
Brian L. Frey, Madison, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
A fast and sensitive method and device for protein sequencing are disclosed. The method uses a combination of Edman degradation chemistry and mass spectrometry to sequence proteins and polypeptides. A peptide degradation reaction is performed on a polypeptide or protein ion reactant in the gas phase. The reaction yields a first ion product corresponding to a first amino acid residue of the polypeptide or protein reactant and a polypeptide or protein fragment ion. The mass-to-charge ratio for the first ion product, or the polypeptide or protein fragment ion, or both, is then determined. The first amino acid residue of the polypeptide or protein reactant is then identified from the mass-to-charge ratio so determined.